From the very beginning of the game you will come across strange Padlocks that you simply cannot unlock.
Remember the location of all such padlocks. After some time, you will have a chance to open each such lock by looking outside the door, inside a cabinet, case or drawer.
You need a lockpick. According to the plot of the game, when you go to the substation to activate the supply of electricity, find the box inside which the lockpick is hidden. Jill will receive a set of lockpicks. You do not have to search for several lockpicks to use one for each lock. Instead, the lockpick found is suitable for unlocking all the locks in Raccoon City.
When you get lockpick, go back to where you saw the yellow padlocks. One of the most important objects is the toy store, where one of the colored gems and the statuette of Mr. Charlie are hidden.