This puzzle is the first serious test of your wits that you will face during the main storyline. After Antonio hands over the bottle of wine, you will have to go to the tower in the Vatican and pour the contents of the bottle into the chalice. Then, by rotating the stone circle 360 degrees, you will descend into the catacombs under the city. It is there that one of the most difficult puzzles in the game awaits you.
If you have played other large action adventure games or watched the Indiana Jones films, then you will already have a general idea of how the puzzles in The Great Circle are arranged. Before solving the main Sacred Wounds puzzle, you will need to explore the surrounding area and solve several smaller problems to gather the necessary information.
When you get to the catacombs under the tower, you will see an image of Jesus with a chalice in front of him. Pour the wine Antonio gave you into the bowl, and five levers will extend from the painting. You can interact with them, but at this point you don’t know how or in what order.
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Return to the main room. It's time to interact with the main painting and set the levers to solve the Sacred Wounds puzzle.
You can move the levers to position II, III, or IV, with each lever corresponding to a different part of Jesus' body. You'll notice that each bowl next to the paintings has a different body part circled on the image of Jesus. The solution is as follows:
After this, the levers will disappear and the painting will turn around, opening the passage to the next part of the mission. Remember this solution, as a similar puzzle with a similar principle will appear later in the game as part of the side quest "Field Research".